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Barcelona vs. Inter Milan Prediction: Expert Picks & Odds for Champions League Semifinal

Gary Pearson

Last Updated: April 29, 2025 1:16 PM EDT • 2 min 60 sec read.

Barcelona welcome Inter Milan to Estadi Olimpic de Montjuic for Wednesday's Champions League semifinal first leg at 3 p.m. ET, with the Catalan side the favorites across our best sports betting sites to draw first blood. 

Our Barcelona vs. Inter Milan prediction expects exactly that, with the irrepressible Spanish side showing its quality at home, where the club is unbeaten in the last 15 Champions League matches. 

Barcelona are the Champions League odds favorites entering proceedings, trading just ahead of PSG and Arsenal. 

💰 Barcelona vs. Inter Milan expert picks: Champions League semifinal

Check out all of our soccer picks for the Champions League and more.

✅ Against the spread pick: Inter Milan +1.5 (-220 via DraftKings) ⭐⭐⭐
✅ Moneyline pick: Barcelona (-155 via DraftKings) ⭐⭐⭐⭐
✅ Over/Under pick: Under 3.5 (-180 via DraftKings) ⭐⭐⭐

💡 Barcelona vs. Inter Milan prediction & best bet

🎯 Score prediction: Barcelona 2, Inter Milan 1 

We're coming to the end of another long, grueling campaign, and Inter Milan is not coping well with the compounding fatigue. The Italian giants have shrunk like a new cotton shirt in the dryer, losing three straight in all competitions while picking up one victory in their previous four away matches. 

Their solo triumph in enemy territory came in the first leg of the quarterfinals against a Bayern Munich team that's dealt with more injuries than a sports medicine doctor's treatment room.

And while Simone Inzaghi's squad is wily and seasoned, it's a shadow of their San Siro selves in hostile environments, winning 12 of their previous 28 away Champions League games (seven draws and nine losses). 

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And then there's Barcelona, who have lost once in the previous 28 games, with that defeat occurring in Germany during the second leg of a quarterfinal that was already wrapped up. They're unbeaten in their previous 15 home Champions League matches and are scoring 3.1 goals per match, the second-best all-time in the competition.

Go with the moneyline pick if you're fine with earning $6.45 on a $10 bet.

I'm backing Barcelona to win and both teams to score due to the wear and tear inflicted on the Catalan side from beating Real Madrid 3-2 on Saturday in the arduous 120-minute Copa del Rey final.  

✅ Best bet: Barcelona to win and both teams to score (+185 via BetMGM)

Live Betting Odds

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⚽ Best Barcelona vs. Inter Milan player prop bet

🔎 Our NEW player prop odds tool can help you find the best betting odds across legal sportsbooks in your area!

🔥 Raphinha anytime goal ⭐⭐⭐⭐

Raphinha has recorded 12 goals in as many Champions League matches, one behind Serhou Guirassy, whose Borussia Dortmund fell victim to Barcelona. He's scoring a goal every 85 minutes and bulged the old onion bag four times in the last four Champions League contests. Of his 30 goals in all competitions, Raphinha has scored 40% in the Champions League. 

However, the 12 Champions League matches represent 24% of the 50 outings he's played. I also like his speed and shiftiness against Inter's defense. Additionally, Robert Lewandowski is unavailable due to injury, placing more of an impetus on Raphinha to produce.

A winning $10 bet at FanDuel, which offers the longest odds of our best sports betting apps, would yield an $18.50 profit. 

✅ Best odds: +185 via FanDuel

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📈 Barcelona vs. Inter Milan odds

Live updated odds from our best sports betting sites.

🚑 Barcelona vs. Inter Milan injury report

📡 How to watch Barcelona vs. Inter Milan live  

📅 Wednesday, April 30 
🕗 3 p.m. ET 
📍 Estadi Olimpic de Montjuic (Barcelona, Spain)
📺 TNT Sports 4 | 🛜 Paramount+ 

💵 Best soccer betting sites

Looking to bet on the UEFA Champions League? Here are the best soccer betting sites and the best sportsbook promos for today's UCL games.

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Written By:
Gary Pearson
Gary Pearson has written professionally since 2010, focusing on sports betting since 2014. Before entering the sports betting space, he contributed to the Canadian Press, FanSided, the Hockey Writers, the Calgary Herald, and other publications. His work has also been featured in Sports Illustrated and Bleacher Report. Gary, who consumes sports like a blue whale devours plankton, has a penchant for writing predictions and analyses across several sports, including hockey, soccer, football, tennis, and more. He bets regularly, preferring single-game picks, props, and live betting. While there isn't a sport he has yet to dabble in, Gary prefers betting on soccer, hockey, and football. He studied at various post-secondary institutions, including the University of Calgary, SAIT Polytechnic, and Griffith University, located in Brisbane, Australia. Gary has a marketing degree and completed his bachelor's degree in journalism at Griffith University. He feels strongly that life experience is as essential as post-secondary education, helping formulate more accurate predictions and analyses. Gary believes that competing at a high level of amateur sports during his formative years helped him better understand an athlete's psyche and the nuances and complexities of a team's dynamic, both on and off the playing surface. He feels that knowledge is immeasurably important when offering his analytical expertise. He has lived on five continents and currently resides in Canada.